Systematic umbrella review finds no evidence that serotonin abnormalities are associated with depression (but don’t stop your drugs suddenly)

Our new review of serotonin research collated research from six different areas. We looked at research on serotonin levels in body fluids, levels of the main metabolite (breakdown product) of serotonin in the cerebro-spinal fluid (brain fluid), serotonin receptors, the serotonin transporter protein (the protein that removes serotonin from the synapse where it is active-…

Psychedelics – the new psychiatric craze!

Psychedelics are an increasingly fashionable medical treatment, but are they anything other than a powerful form of snake oil, or a recreational experience? Do they have any objective health benefits? Can we be confident they are safe? These questions need answering urgently as the number of people being enticed or persuaded to have these drugs is increasing. Here I draw attention to some of the issues raised by the current popularity of these drugs.

What can we learn from the asylum? Historical study of the Essex County Asylum reflects the perennial functions of the mental health system

Summary My historical study of the Essex asylum, just outside London, which was recently published in Psychological Medicine, finds that those who were admitted showed significant disturbances of behaviour or evidence of organic disease. Almost two thirds of those who had psychological, as opposed to organic, disorders were discharged recovered or improved (mostly recovered). The…

The uniqueness of life: a review of Peter Hacker’s “Human Nature: the Categorial Framework” and its implications for the mind-body problem and our understanding of mental disorder

Peter Hacker is an eminent philosopher and one of the world’s leading authorities on Wittgenstein. He has published a four volume analytical commentary on the Philosophical Investigations and a brilliant little book on Wittgenstein’s philosophy of mind, now sadly out of print (1). He is also well known for his debunking of neuroscientific reductionism in…