Our umbrella review that revealed no links between serotonin and depression has caused shock waves among the general public, but been dismissed as old news by psychiatric opinion leaders. This disjunction begs the questions of why the public have been fed this narrative for so long, and what antidepressants are actually doing if they are…
Summary: I respond to some of the points in the recent Rolling Stone article and correct the many inaccuracies and distortions. Ignoring is no longer working, so champions of big Pharma and mainstream psychiatry have gone into attack mode. The strategy is to undermine the messenger (me) in order to neutralise the message. In this…
Summary TL;DR For decades people have been told that depression is caused by a serotonin deficiency. This was the rationale behind the introduction of the SSRI (Selective Serotonin Reuptake Inhibitor) antidepressants in the 1990s, which were thought to work by boosting low levels of serotonin. Our research shows no evidence of low serotonin in depression,…
Our new review of serotonin research collated research from six different areas. We looked at research on serotonin levels in body fluids, levels of the main metabolite (breakdown product) of serotonin in the cerebro-spinal fluid (brain fluid), serotonin receptors, the serotonin transporter protein (the protein that removes serotonin from the synapse where it is active-…
In this blog I reflect on what has and has not changed in the field of psychiatric drug treatment in the years between the first and newly published second edition of the Straight Talking Introduction to Psychiatric Drugs.
The recent furore caused by publication of evidence about the serious nature of antidepressant withdrawal made me reflect on the lasting damage that can sometime be done by prescription drugs, and how it has often taken concerted efforts by users of these drugs to bring these effects to public attention. Historically, the medical community…
German psychiatrist, Stefan Leucht and colleagues, have produced another really important paper (1). The results indicate that the small differences usually found between antidepressants and placebo are far below the sort of differences that would be clinically detectable or meaningful. Leucht et al have conducted the first thorough, systematic attempt to provide some empirical evidence…
A long overdue debate is raging about the chemical imbalance theory of depression. Having been deluged with this idea for two decades now, the general public has come to believe that it is a scientifically proven fact. An LBC radio presenter recently announced that he had suffered from depression and he knew it was a…
People have used psychoactive substances to dull and deaden pain, misery and suffering since time immemorial, but only recently, in the last few decades, have people been persuaded that what they are doing in this situation is rightly thought of as taking a remedy for an underlying disease. The spread of the use of prescription…
Antidepressants have been in the news recently. The general feeling seems to be that although they are being overused and may have some unpleasant side effects, they certainly ‘work,’ at least in some people (1). So what is the evidence that antidepressants ‘work’? If you compare them with a dummy tablet or placebo in a…
Joanna Moncrieff 