Contradictory responses to our review of serotonin and depression

After the publication of our umbrella review of serotonin last summer, several psychiatrists wrote letters to the journal, Molecular Psychiatry, as usually occurs after the publication of a major finding. We were invited by the editor of the journal to respond to the points raised in the letters, again a routine procedure in scientific literature.…

Why there’s no such thing as an ‘antidepressant’

Antidepressants have been in the news recently. The general feeling seems to be that although they are being overused and may have some unpleasant side effects, they certainly ‘work,’ at least in some people (1). So what is the evidence that antidepressants ‘work’? If you compare them with a dummy tablet or placebo in a…